The Juventus star was due to feature for Portugal tomorrow in their Nations League Group C clash against Sweden.
The 35-year-old has been released by the national side and must now isolate.
Cristiano Ronaldo was released from the work of the National Team after a positive test for COVID-19, so he will not face Sweden.
Ronaldo is reported to be in good health and has no symptoms. He is the only member of the Portugal squad to test positive.
The news comes just days after Ronaldo featured in Portugal’s goalless draw with France.
Ronaldo is the latest world star to contract the virus.